Perry was born in Williamstown, Massachusetts in 1969 to his mother, Suzanne Marie Morrison, and father, actor John Bennett Perry. After moving in with his father as a teenager, Perry opted to follow in his footsteps. He starred in a number of television series such as Second Chance and Growing Pains before landing the role of Chandler Bing on Friends in 1994. He was nominated for an Emmy in 2002 for his portrayal of Bing, but ultimately lost to Ray Romano.
Perry starred in countless moves aside from his iconic role in Friends, such as Fools Rush In, Almost Heroes, The Whole Nine Yards, 17 Again, and more. He was also known for his drama role as John Quincy in The West Wing.
He has been outspoken about his struggle with addiction in recent years, which he chronicled in his 2022 memoir Friends, Lovers, and the Big Terrible Thing. Perry leaves behind no spouse or children.